What is mixed cryoglobulinemia
Cryoglobulinemia type II is also called mixed cryoglobulinemia. It’s defined by the presence of both cryoglobulins types: monoclonal and polyclonal. It is defined as secondary disease if it is accompanied by certain diseases such as autoimmune diseases, chronic inflammation, infections or cancer of the lymphatic system. If there is no found cause of cryoglobulinemia symptoms then it’s called essential mixed cryoglobulinemia. In a large proportion of patients with idiopathic mixed cryoglobulinemia it is concluded hepatitis C.
The disease is chronic with periodic relapses. The indication for treatment is when the disease affects the kidneys, liver, or small vessels and peripheral nerves. Mixed cryoglobulinemia is the most common type of this disease.
Mixed cryoglobulinemia most fraquently occurs in middle-age woman.
Common symptoms of essential mixed cryoglobulinemia
Learn about Cryoglobulinemia
Cryoglobulinemia is known as a systemic disease characterized by presence in blood of immune complexes called cryoglobulins. To understand Cryoglobulinemia you need to know what is cryoglobulin. It is abnormal protein (immunoglobulin) which precipitate and is irresolvable at low body’s temperature. When temperature decreases it’s again dissolvable. Blood levels of cryoglobulin in healthy person may reach 30 mg/L. It is involved in vascular damage, renal and neurological complications. Disease accompanies mostly chronic inflammation, autoimmune diseases and infectious.
There is certainly a correlation between hepatitis C infection and type II cryoglobulinemia. Symptoms of Cryoglobulinemia occur when concentration of cryoglobulin is above 100 mg/L. The clinical symptoms characteristic for Cryoglobulinemia are blotchy rash, joint pain and persistent fatigue.
Types of cryoglobulinemia
Cryoglobulinemia is classified in three types based on the composition of cryoglobulin present in serum: