What is cryoglobulin?
Cryoglobulins are immunoglobulins that at temperatures lower than normal body temperature undergo spontaneous precipitation and cause its transformation to a gel, however after heating they obtain the solubility again. At low concentrations, precipitation occurs in the temperature of about 4 ° C, although the increased the blood concentration at upper temperatures can reach it.In healthy individuals may experience a tiny quantity cryoglobulins – about 35 mg / l, but symptoms most often occur at concentrations above 100 mg / l. Occasionally it could actually happen finding the concentrations of over than 1000 mg/l with the absence of symptoms.
Learn about Cryoglobulinemia
Cryoglobulinemia is known as a systemic disease characterized by presence in blood of immune complexes called cryoglobulins. To understand Cryoglobulinemia you need to know what is cryoglobulin. It is abnormal protein (immunoglobulin) which precipitate and is irresolvable at low body’s temperature. When temperature decreases it’s again dissolvable. Blood levels of cryoglobulin in healthy person may reach 30 mg/L. It is involved in vascular damage, renal and neurological complications. Disease accompanies mostly chronic inflammation, autoimmune diseases and infectious.
There is certainly a correlation between hepatitis C infection and type II cryoglobulinemia. Symptoms of Cryoglobulinemia occur when concentration of cryoglobulin is above 100 mg/L. The clinical symptoms characteristic for Cryoglobulinemia are blotchy rash, joint pain and persistent fatigue.
Types of cryoglobulinemia
Cryoglobulinemia is classified in three types based on the composition of cryoglobulin present in serum: