What is cryoglobulin?
Cryoglobulins are immunoglobulins that at temperatures lower than normal body temperature undergo spontaneous precipitation and cause its transformation to a gel, however after heating they obtain the solubility again. At low concentrations, precipitation occurs in the temperature of about 4 ° C, although the increased the blood concentration at upper temperatures can reach it. In healthy individuals may experience a tiny quantity cryoglobulins – about 35 mg / l, but symptoms most often occur at concentrations above 100 mg / l. Occasionally it could actually happen finding the concentrations of over than 1000 mg/l with the absence of symptoms.