What is cryoglobulin?
Cryoglobulins are immunoglobulins that at temperatures lower than normal body temperature undergo spontaneous precipitation and cause its transformation to a gel, however after heating they obtain the solubility again. At low concentrations, precipitation occurs in the temperature of about 4 ° C, although the increased the blood concentration at upper temperatures can reach it.In healthy individuals may experience a tiny quantity cryoglobulins – about 35 mg / l, but symptoms most often occur at concentrations above 100 mg / l. Occasionally it could actually happen finding the concentrations of over than 1000 mg/l with the absence of symptoms.
When it involves the precipitation, vasculitis and once in a while of renal involvement and neurologic symptoms may occur. Circulating cryoglobulins are detected in the several chronic infections, lymphoproliferative disorders, blood diseases and autoimmune disorders. In mixed cryoglobulinemia in about 90% of cases pateits have a viral infection with hepatitis C.
When should you perform cryoglobulin’s test?
- cutaneous vasculitis
- ischemia of the peripheral parts of the body
- Raynaud’s syndrome
- monoclonal gammopathy
- cold-induced cyanosis of ears, nose, fingers
- redness of the skin
- HCV and HBV infection
- Sjogren’s syndrome
- unexplained peripheral neuropathy